Signalling through C-type lectin receptors: shaping immune responses

Signalling C-Type lectin receptors, microbial recognition and immunity

Signalling C-type lectin receptors (CLRs) are crucial in shaping the immune response to fungal pathogens, but comparably little is known about the role of these receptors in bacterial, viral and parasitic infections. CLRs have many diverse functions depending on the signalling motifs in their cytoplasmic domains, and can induce endocytic, phagocytic, antimicrobial, pro-inflammatory or anti-infl...

Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptors

The vertebrate gut symbiont Lactobacillus reuteri exhibits strain-specific adhesion and health-promoting properties. Here, we investigated the role of the mucus adhesins, CmbA and MUB, upon interaction of L. reuteri ATCC PTA 6475 and ATCC 53608 strains with human monocyte-derived dendritic cells (moDCs). We showed that mucus adhesins increased the capacity of L. reuteri strains to interact with...

Enhanced dendritic cell-induced immune responses mediated by the novel C-type lectin receptor mDCAR1.

The dendritic cell (DC) immunoreceptors (DCIR) and DC-immunoactivating receptors (DCAR) represent a subfamily of cell surface C-type lectin receptors (CLR), whose multifunctional capacities range from classical Ag uptake and immunoregulatory mechanisms to the involvement in DC ontogeny. On the basis of the generation of specific mAbs, we functionally characterized mouse DCAR1 (mDCAR1) as a memb...

SHP-2 Mediates C-type Lectin Receptors-induced Syk Activation and Anti-fungal TH17 Responses

Zihou Deng1, Shixin Ma1, Hao Zhou2, Aiping Zang1, Yiyuan Fang1, Tiantian Li1, Huanjing Shi1, Mei Liu1, Min Du1, Patricia R. Taylor3, Helen H. Zhu4, Jiangye Chen5, Guangxun Meng1, Fubin Li6, Changbin Chen1, Yan Zhang1, Xin-Ming Jia7, Xin Lin8, Xiaoming Zhang1, Eric Pearlman3, Xiaoxia Li2, Gen-Sheng Feng9, and Hui Xiao1,*,¶ 1Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of...

Lectin Receptor mDCAR1 Responses Mediated by the Novel C-Type Enhanced Dendritic Cell-Induced Immune